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HCMV regulation of EGFR signaling pathways. A proposed model for the interactions of HCMV proteins and miRNAs with the EGFR signaling pathways is presented. Our data demonstrate that miR-US5-2 downregulation of GAB1 dampens MEK/ERK and PI3K signaling pathways, which ultimately affects the expression of EGR1 and UL138. We propose that interference with the EGFR-EGR1-UL138 signaling loop is a component of the switch from latent to lytic replication.
