FIG 4.

Giardia infection in children is associated with a reduction in Gammaproteobacteria regardless of disease status. (A) LEfSe graph showing the magnitude of enrichment for each taxon with LDA score of >2 comparing children with and without Giardia infection. (B and C) Boxplots showing the relative abundance of differentially enriched taxa among children with MSD (B) and those without MSD (C). A very similar set of taxa are differentially expressed during Giardia infection regardless of clinical disease. Although the relative abundance of Gammaproteobacteria and Prevotella are different between MSD and non-MSD, Giardia infection is significantly associated with a reduction of Gammaproteobacteria and enrichment of Prevotella regardless of MSD status. Taxa were collapsed to the genus level when possible; however, Gammaproteobacteria, Clostridiales, and Lachnospiraceae were only able to be collapsed to the class, order, and family, respectively.