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. 2020 Jul 14;12(7):660. doi: 10.3390/pharmaceutics12070660

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Examples of Predictive software for Vd. T2-weighted MRIs showing (A) actual catheter positioning prior to infusion; (B) predicted Vd before infusion (green outline; 9.8 mL); (C) actual Vd following infusion determined as ΔT2 (blue outline; 9.6 mL); (D) overlap between predicted (green) and actual (blue) Vd. (E) PET image showing actual tracer distribution following delivery. (F) Magnified PET image showing actual tracer distribution following delivery projected over predicted Vd (green) and actual Vd (ΔT2, blue). Images courtesy of Eva Wembacher, BrainLab (Munich, Germany).