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. 2020 Jul 16;9(7):1710. doi: 10.3390/cells9071710

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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TLR7 correlates with M2 macrophage markers in healthy, intermediate, and calcified parts of the aortic valve. (a) TLR7 mRNA levels were significantly increased in calcified compared with healthy and intermediate parts of the aortic valve (n = 55). 1-way RM ANOVA with Holm-Sidak post-hoc test, **** p ≤ 0.0001. (b–d) Correlation analysis of TLR7 mRNA levels with mRNA levels of the VIC marker gene vimentin as well as immune cell markers in healthy (b), intermediate (c), and calcified (d) parts of human aortic valves (n = 55). Pearson correlation and false discovery rate (FDR) adjusted p-values are presented.