Figure 2.
Activity of compound 6 in human embryonic lung (HEL) cells infected with human coronavirus 229E. (A) Representative images showing complete inhibition of viral CPE at non-toxic compound concentrations (reference compound: UDA lectin). (B) Reduction in virus yield, as determined by RT-qPCR for viral RNA in the supernatant at day 4 p.i. (lower limit of detection: 102 copies). Curve fitting by GraphPad Prism, on two data points from one experiment performed in duplicate. Full grey line: virus yield for untreated virus control; red dashed line: 100-fold reduction in virus yield.