Skip to main content
. 2020 Jul 8;9(7):1642. doi: 10.3390/cells9071642

Figure 1.

Figure 1

Mechanism of the formation and activation of the NLRP3 inflammasome (detailed description in Section 2.1). Signal 1 (priming): activation of NF-κB (nuclear factor kappa B) by DAMPs/PAMPs through TNFR (tumor necrosis factor receptor), TLR (Toll-like receptor), and IL-1R (interleukin 1 receptor). NF-κB stimulates the production of NLRP3 and pro-IL-1β. Signal 2 (activation): DAMPs/PAMPs connects directly to the NLRP3, changes its confirmation and leads to its multimerization and inflammasome formation. Active inflammasome recruits and activates caspase 1, which in turn activates IL-1β, IL-18 and gasdermin D.