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Fit model statistics of SMV-EMLs responses prepared according to Box–Behnken design.
| Responses | Model | Sequential p-Value | Lack of Fit p-Value | R2 | Adjusted R2 | Predicted R2 | Adequate Precision | PRESS | Significant Terms |
|---|---|---|---|---|---|---|---|---|---|
| Y1: Vesicle size (nm) | Quadratic | 0.0054 | 0.1374 | 0.9957 | 0.9902 | 0.9492 | 46.0233 | 631.46 | X1, X2, X3, X1X3, X2X3, X32 |
| Y2: Entrapment Efficiency (%) | Linear | <0.0001 | 0.2024 | 0.9678 | 0.9604 | 0.9426 | 37.0236 | 31.18 | X1, X2 |
