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. 2020 Jul 13;9(7):1678. doi: 10.3390/cells9071678

Figure 2.

Figure 2

Disease-associated mutations in MRE11. Top, domain architecture of MRE11. The numbers below indicate the position of mutations outlined in the text and in Table 1. Red, green, and blue numbers correspond to mutations associated with cancer, ATLD, and NBSLD, respectively. The two arrows above indicate the position of the NBS1 interacting regions. Bottom, crystal structure of the MRE11 nuclease and capping domain dimer from C. thermophilum (PDB ID: 4YKE). Since the helix-loop-helix and GAR domains are absent in this structure, they are cartooned in (not to scale).