Table 3.
Apparent permeability values of the chlorogenic acid and the narcissin from Calendulae flos lyophilized extract and its chitosan delivery systems.
| Substance | Papp ± SD (×10−6 cm s−1) | |
|---|---|---|
| Chlorogenic Acid | Narcissin | |
| Reference substances | 2.42 ± 1.18 | 2.35 ± 1.46 |
| Calendulae flos lyophilized extract | 2.90 ± 1.76 | 1.44 ± 0.68 |
| Calendulae flos lyophilized extract—chitosan 80/500 1:1 (w/w) | 2.97 ± 0.01 | 1.63 ± 0.01 |
| Calendulae flos lyophilized extract—chitosan 80/1000 1:1 (w/w) | 3.20 ± 0.41 | 1.60 ± 0.06 |
Compounds with Papp < 1 × 10−6 cm s−1 = low-permeable compound, those with Papp > 1 × 10−6 cm s−1 = high-permeable compounds [44].