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. 2020 Jan 23;189(8):747–754. doi: 10.1093/aje/kwaa001

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© The Author(s) 2020. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Simulated power for a planned study to detect a 3-level correlate of protection (CoP) in vaccinees at overall vaccine efficacy (VE) = 0.75 with a trichotomous marker by fractions of vaccinees with low VE and high VE (1-sided ). There are 250 controls and 50 cases; controls:cases = 5:1. The percentage with low value of immune marker = percentage with low VE; the percentage with high value of immune marker = percentage with high VE; precision .

Inline graphic — Simulated power for a planned study to detect a 3-level correlate of protection (CoP) in vaccinees at overall vaccine efficacy (VE) = 0.75 with a trichotomous marker by fractions of vaccinees with low VE and high VE (1-sided ). There are 250 controls and 50 cases; controls:cases = 5:1. The percentage with low value of immune marker = percentage with low VE; the percentage with high value of immune marker = percentage with high VE; precision .