Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 6;9(7):1627. doi: 10.3390/cells9071627

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

The SLC1 is taken up by the endothelial cell via E-selectin-mediated endocytosis and reaches upon engulfment a late endosomal compartment; via the KDEL-receptor bearing Golgi, SLC1 is passed through the ER in a retrograde fashion. In the ER, the ETAII is cleaved by furin and the C-terminal NBP element is released into the cytoplasm. Subsequently the recombinant NBP traps NEMO and leads to inhibition of IKK complex assembly (right panel). As SLC1 treatment results in a blockade of IKK assembly, subsequent steps of cytokine-induced NF-kappaB activation and finally translocation of p50/p65 dimers into the nucleus are blocked in the endothelial cells (blocked steps are marked with red crosses).