Table 1.

Molecules that act as Damage-Associated Molecular Pattern (DAMPs), associated pattern recognition receptors (PRRs) and described biological functions.

Danger Signal	PRR	Function
CALR HSP70 HSP90	LRP1	Promotes the uptake of dead cell-asociated antigens.
Extracellular ATP	P2RX7/P2RY2	Favours the recruitment of APCs and their activation.
HMGB1 dsRNA Cellular RNA LPS Flagellin ssRNA CpG DNA Viral RNA dsDNA	TLR2/TLR4 TLR3 TLR3 TLR4 TLR5 TLR7 TLR9 RLRs CDSs	Activate the synthesis of pro-inflammatory factors (type I IFNs).
Type I IFNs	IFNAR	Promotes CXCL10 secretion by cancer cells and has immune-stimulatory effects.
ANXA1	FPR1	Guides the final approach of APCs to dying cells.
CXCL10	CXCR3	Favours T cell recruitment.

Caption: ANXA1, annexin A1; APC, antigen-presenting cell; CALR, calreticulin; CDS, cytosolic DNA sensor; CXCL10, CXC-chemokine ligand 10; CXCR3, CXC-chemokine receptor 3; ds, double-stranded; FPR1, formyl peptide receptor 1; HMGB1, high-mobility group box 1; HSP70, heat shock protein 70 kDa; HSP90, heat shock protein 90 kDa; IFN, interferon; IFNAR, interferon α/β-receptor; LRP1, LDL receptor related protein 1; P2RX7, purinergic receptor P2X7; P2RY2, purinergic receptor P2Y2; RLR, RIG-I-like receptor; ss, single-stranded; TLR, Toll-like recept.