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(A) Scheme depicting the reactions catalyzed by wild type and mutant IDH enzymes and their respective effects on the provision of NADPH for the reduction of GSSG to GSH by glutathione reductase. (B) Effect of different IDH1/2 mutations on the GSH/GSSG ratio in HCT116 cells compared to IDH1/2 wild type cells. * p < 0.05, ** p < 0.01, *** p < 0.001, n = 3, for further statistics see Supplementary Table S5.
