Table 1.
Three genetic variants as independent BC risk predictors obtained from stepwise logistic regression analysis in the DRIVE study
| SNP1 | Location | MAF | Category2 | Frequency | OR (95% CI)1 | P 1 |
|---|---|---|---|---|---|---|
| SNAI1 rs1047920_T | 20q13.13 | 0.07 | CC/CT/TT | 45730/6957/276 | 0.93 (0.88-0.97) | 0.0014 |
| AMDHD1 rs11826_T | 12q23.1 | 0.24 | CC/CT/TT | 30973/18993/2997 | 0.96 (0.93-0.98) | 0.0020 |
| CUBN rs3914238_T | 10p13 | 0.38 | CC/CT/TT | 20752/24693/7518 | 1.04 (1.01-1.07) | 0.0022 |
Stepwise logistic regression analysis included age, PC1, PC3, PC4, PC5, PC6, PC8, PC10, PC11, PC14, PC16, four previously published risk-associated SNPs (rs1323697, rs1264308, rs141308737 and rs1469412) in the same study by Jie Ge (PMID: 31026346) and 11 SNPs (rs3914238, rs1047920, rs7913144, rs7898138, rs11424438, rs2271464, rs77090490, rs4141977, rs11826, rs1800629 and rs1800628).
The most left-hand side “category” was used as the reference.
Note: there were 20 PCs in the combined datasets as listed in Supplementary Table 3, of which ten remained significant and were adjusted in the final stepwise logistic regression analysis. Abbreviations: AMDHD1, amidohydrolase domain containing 1; BC, breast cancer; CI, confidence interval; CUBN, cubilin; DRIVE, Discovery, Biology, and Risk of Inherited Variants in Breast Cancer; SNP, single nucleotide polymorphism; MAF, minor allele frequency; OR, odds ratio; SNAI1, snail family transcriptional repressor 1.