Table 2.

Associations between three independent SNPs in the vitamin D pathway genes and BC risk in the DRIVE study

Genotype	N Control/N Case	Univariate analysis		Multivariate analysis1
		OR (95% CI)	P	OR (95% CI)	P
SNAI1 rs1047920 C>T
CC	20787/24943	1.00		1.00
CT	3324/3633	0.91 (0.87-0.96)	0.0003	0.91 (0.87-0.96)	0.0003
TT	124/152	1.02 (0.81-1.30)	0.861	1.02 (0.80-1.30)	0.869
Trend test			0.001		0.001
CT+TT	3448/3785	0.92 (0.87-0.96)	0.0004	0.91 (0.87-0.96)	0.0004
AMDHD1 rs11826 C>T
CC	14033/16940	1.00		1.00
CT	8761/10232	0.97 (0.93-1.00)	0.074	0.97 (0.93-1.00)	0.069
TT	1441/1556	0.89 (0.83-0.96)	0.004	0.89 (0.82-0.96)	0.002
Trend test			0.002		0.002
CT+TT	10202/11788	0.96 (0.93-0.99)	0.013	0.96 (0.92-0.99)	0.011
CUBN rs3914238 C>T
CC	9676/11076	1.00		1.00
CT	11183/13510	1.06 (1.02-1.10)	0.004	1.05 (1.02-1.09)	0.006
TT	3376/4142	1.07 (1.02-1.13)	0.010	1.07 (1.01-1.13)	0.014
Trend test			0.002		0.003
CT+TT	14559/17652	1.06 (1.02-1.10)	0.001	1.06 (1.02-1.10)	0.002
Number of combined risk genotypes2
0	596/628	1.00		1.00
1	5128/5640	1.04 (0.93-1.18)	0.475	1.05 (0.93-1.18)	0.451
2	11284/13489	1.14 (1.01-1.27)	0.031	1.14 (1.01-1.28)	0.028
3	7232/8976	1.18 (1.05-1.32)	0.006	1.18 (1.05-1.33)	0.005
Trend test			<0.0001		<0.0001
0-2	17008/19757	1.00		1.00
3	7232/8976	1.07 (1.03-1.11)	0.0005	1.07 (1.03-1.11)	0.0005

Abbreviations: AMDHD1, amidohydrolase domain containing 1; BC: breast cancer; CI: confidence interval; CUBN, cubilin; DRIVE: Discovery, Biology, and Risk of Inherited Variants in Breast Cancer; OR: odds ratio; SNAI1, snail family transcriptional repressor 1; SNP: single nucleotide polymorphism.

¹Adjusted for age, PC1, PC3, PC4, PC5, PC6, PC8, PC10, PC11, PC14 and PC16.

²Risk genotypes were rs1047920 CC, rs11826 CC and rs3914238 CT+TT.