Table 4.
Studies presenting the use of EBC in lung cancer (year of publication 2015-2019)
| EBC collection device | Study population | Type of analysis performed | Ref |
|---|---|---|---|
| EcoScreen-1 (Erich Jaeger GmbH, Hochberg, Germany) with saliva trap | 51 patients with a diagnosis of NSCLC | KRAS mutations identification | [80] |
| Rtube condensate collector device (Model Austin, TX 78720; RTube starter kit; Respiratory Research Inc., Austin, TX) | 60 patients with lung cancer who underwent lung resection | Evaluation of TNF-α, IL-1β expression levels | [81] |
| RTube condenser (Model Austin TX 78720; RTube starter kit; Respiratory Research Inc., Austin, TX, USA) | 60 patients with lung cancer undergoing a unilateral lobectomy | Evaluation of surfactant protein A and surfactant protein D expression levels | [82] |
| EcoScreen 2 device (FILT Lungen-und Thoraxdiagnostik, Berlin, Germany) | 192 individuals the control group n = 49; smoking group n = 49 | Proteomic analysis | [83] |
| the chronic obstructive pulmonary disease group n = 46; | |||
| lung cancer group n = 48 | |||
| RTube (Respiratory Research) | 61 ctr and 50 NSCLC and 1 SCLC-FFPE Tissue | Evaluation of GATA6 and NKX2-1 expression | [84] |
| 143 ctr, 99 NSCLC, and 9 SCLC-EBC samples | |||
| HAAK EK20 EcoScreen; Eric Jaeger, Friedberg, Germany | 58 patients with NSCLC, 30 healthy subjects were selected | Evaluation of the mutational status of exons 1 and 2 of the p16 gene | [85] |