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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Self-renewal mechanisms of stem cells. Stem cells are defined by their ability to make new stem cells (self-renewal). Self-renewal of stem cells is divided into two processes: Generation of daughter cells or of cells fated to differentiate.