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Proposed LOCD device. (A) Two-dimensional schematic of the designed centrifugal-based microfluidic biochip composed of serially arranged separator and mixer subunits. (B) Magnified view of the proposed device. (C) Cell separation unit, the CTCs are separated from the WBC cells by the implementation of inertial contraction–expansion arrays. (D) The mixer unit for cell lysis: (I) serpentine channel without obstacles and (II) with obstacles.
