Table 6.

miR/ZEB2 regulation by various molecular pathways in different cancers.

Upstream Mediator	MiR	Down-Stream Target	Cancer Type	Major Outcomes	Refs
P53	MiR-30a	ZEB2	Breast cancer	P53 stimulates the expression of miR-30a to upregulate ZEB2, resulting in reduced viability, proliferation, and invasion of cancer cells	[169]
EZH2-DNMT1	MiR-142-3p	ZEB2	Nasopharyngeal carcinoma	The EZH2-DNMT1 induces ZEB2 through miR-142-3p sponging, resulting in an increase in cancer progression	[380]
CircNUP214	MiR-145	ZEB2	Thyroid cancer	CircNUP214 induces ZEB2 through miR-145 down-regulation to enhance the malignancy and progression of cancer cells	[381]
CircPCNXL2	MiR-153	ZEB2	Renal cancer	The circPCNXL2 stimulates the expression of ZEB2 through miR-153 down-regulation to suppress the malignancy and invasion of cancer cells	[201]
FOXP3	MiR-155	ZEB2	Human breast cancer	FOXP3 and miR-155 synergistically down-regulate the expression of ZEB2 to diminish the invasiveness of cancer cells	[382]
Akt/ERK	MiR-200c	ZEB2	Gastric cancer	The inhibition of Akt/ERK enhances the expression of miR-200c to suppress IGF-I-mediated ZEB2, leading to the reduced invasion and EMT of cancer cells	[383]
β1 integrin	TGF-β/miR-200	ZEB2	Triple negative breast cancer	Enhancing the expression of β1 integrin reduces the metastasis of cancer cells into lung. This is followed by disrupting TFG−β/miR-200/ZEB2, elevating the E-cadherin levels, and restoring the cohesion of cells	[384]
CircZFR	MiR-377	ZEB2	Bladder cancer	Enhanced progression and malignancy of cancer cells result from down-regulation of miR-377 by circZFR and subsequent induction of ZEB2	[196]
Hsa-circ-0004771	MiR-653	ZEB2	Breast cancer	MiR-653 reduces the expression of ZEB2 and is associated with desirable prognosis. Hsa-circ-0004771 diminishes miR-653 expression to induce ZEB2, leading to the inhibition of apoptosis and enhanced migration and invasion of cancer cells	[197]