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C. elegans models of chronic neuronal damage. (A) In the mec-4(d) excitotoxic model of C. elegans mechanosensory neurons, intracellular calcium increase and mitochondrial dysfunction produce oxidative stress, which triggers neurodegeneration and eventually an impaired touch response. (B) Relieving oxidative stress with various strategies protects neurons against degeneration and rescues touch response defects.
