Table 1.

Indicative experimental parameters used for the preparation of chitosan (CS) nanoparticles with sodium tripolyphosphate (TPP) and some of the characteristics of the obtained nanoparticles. PDI: polydispersity index.

CS/TPP Mass Ratio	Stirring Rate and Time	Size (nm)	ζ-Potential (mV)	PDI	Ref.
5/1	1000 rpm 90 s	214.7 ± 20.1	+21.79 ± 8.17	0.172 ± 0.022	[129]
4/1	100 rpm	342 ± 8	-	narrow, unimodal	[130]
4/1 a	sonication 15 min	295.3 ± 3.0	+29.3 ± 1.8	0.185 ± 0.016	[131]
4/1 b	sonication 15 min	336 ± 22.1	+22.5 ± 1.8	0.246 ± 0.07	[131]
11/3	300 rpm 10 min	81.9 ±10.1	-	0.244 ± 0.07	[132]
3/1	500 rpm 120 min	401.5 ± 14.3	+31.3 ± 3.5	0.198 ± 0.054	[133]
3/1	1000 rpm 2 h	172.3 ± 9.0	+36.46 ± 0.59	0.251 ± 0.001	[134]
2.5/1	1200 rpm 6 h	131.9 ±3.5 c	-	0.406 ± 0.03 d	[135]
		161.9 ±3.3 d	+30.43 ± 1.0 d	0.321 ± 0.054 d
2/1	1000 rpm 2 h	188.5 ± 8.5	+36.86 ± 0.70	0.22	[136]
2/1	800 rpm	287 ± 17	+37.59	0.78	[137]
1.875/1	-	147.2 ± 15.3	+19.4 ± 0.8	0.22 ± 0.04	[138]
1/1	- 18 h	350.6	+33.7	-	[139]
1/2	8000 rpm 20 min	57.0	+27.90	0.02	[140]

^a: low molecular weight chitosan, ^b: high molecular weight chitosan, ^c: empty nanoparticles, ^d: drug-loaded nanoparticles.