Figure 1.

The genomic features and protein structure of thyroid stimulating hormone receptor (TSHR). (A) Schematic representation of the genomic structure of TSHR gene. The corresponding numbers of nucleotides and amino acids for the protein domains within the coding region are shown in this diagram. SP, signal peptide. LRR, leucine-rich repeat domain. TMD, transmembrane domain. CD, intracytoplasmic domain. (B) The schematic diagram represents the folded protein structure of TSHR, in which a large extracellular domain, including the hinge and leucine-rich repeat domain, the transmembrane domain and the intracytoplasmic domain are depicted. Cys, cysteine, where disulfide bonds formed.