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. 2020 Jul 13;10(7):287. doi: 10.3390/metabo10070287

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Changes of endogenous (non-labeled) purine metabolites in ipsilateral striatum after ethyl pyruvate (EP) and placebo treatment. Vasoconstriction of the medial cerebral artery (MCA) was induced by ET-1 infusion in the piriform cortex (150 pmol/15 µL/15 min) starting at time = 0 h. Blue symbols and line indicate data for rats treated with EP immediately after ET-1 infusion (n = 5). Red symbols and line indicate data for control rats (placebo treatment after ET-1, n = 6). Metabolite data are expressed as mean ± SEM of percentage change of each rat’s own baseline.