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. 2020 Jul 7;13(7):144. doi: 10.3390/ph13070144

Figure 6.

Figure 6

Ectopic upregulation of miR-101-3p in breast cancer cells attenuates their transmigration through the brain endothelium by reducing COX-2-MMP1 expression.MDA-MB-231-TGL and MDA-MB-231-BrM2 cells were transfected with miR-101-3p mimic (5 nM final concentration) or with scrambled control. (A) Relative PTGS2, ST6GALNAC5 and HBEGF mRNA measured by real time PCR in control and miR-101-3p mimic transfected cells. (B) Western Blot analysis of COX-2 and MMP1 in control and anti-miR-101-3p transfected MDA-MB-BrM2 cells. Data are mean ±SD from three independent experiments. *** p < 0.001.