Figure 1.

Functional domains of WIP. Schematic description of WIP (1–503) highlighting binding partners and motifs. Actin-binding, cortactin-binding, and WASp-binding regions are shown in green, pink (faded, indicating a putative binding domain), and orange, respectively. Polyproline motifs are shown in light blue (and extended in scale for clarity) with names of binding partners above (red). Sequence numbers are shown for motifs and domains. The actin-binding and WASp-binding regions are magnified (above and below, respectively) to highlight specific sequence features and epitopes. In the former, a red sawtooth pattern indicates the WH2 domain amphiphilic helix.