Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jul 8;9(7):1641. doi: 10.3390/cells9071641

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Effects of dabrafenib on the activation of human, mouse and zebrafish pregnane X receptor (PXR) and human constitutive androstane receptor (CAR) nuclear receptors as measured by luciferase reporter assay. Activation has been measured in (A) HG5LN control cells or cells expressing GAL4 fusion with (B) human (hPXR), (C) mouse (mPXR) or (D) zebrafish (zfPXR) PXR, (E) human wild-type (hCAR) or (F) mutated (hCAR APYLT) hCAR LBD treated by DMSO (0.1%), SR12813 3 μM, PCN 3 μM, clotrimazol 1 μM, CITCO 1 μM and dabrafenib 3 μM. Results are expressed as fold induction as compared to control. Data are expressed as the mean ± sd of three independent experiments, **** p < 0.0001, *** p < 0.001, ** p < 0.01 (Student’s t-test) compared with DMSO-treated cells.