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Dabrafenib binds to hPXR. Inhibition of FRET between fluorescein-labeled PXR ligand and recombinant GST-hPXR by SR12813 or dabrafenib. Results are expressed as the signal from the fluorescein emission divided by the terbium signal to provide a TR-FRET emission ratio. Data are the mean (±sd) from three independent experiments, *** p < 0.001, ** p < 0.01, * p < 0.1 (Student’s t-test) compared with DMSO-treated cells.3.3. Induction of hPXR-Mediated Proliferation by Dabrafenib.
