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hAEC transplantation decreases the irregularity of estrous cycles. A. Representative photograph of proestrus, estrus, metestrus, and diestrus. B. The percentage of regular estrous cycles in rats before CTX injection, 1 week after CTX exposure and 1 week after cell transplantation in 4 groups. hAEC transplanted rats had more regular estrous cycles than POI rats. Scale bar: 100 μm. Magnification ×200. hAEC, human amniotic epithelial cell; POI, primary ovarian insufficiency.
