Figure 5.

Histopathological examination and follicle counts in ovaries. A. The pathological changes in ovaries were identified by H&E staining 2 weeks after cell transplantation. The ovaries of rats contained numerous fibrotic and granulosa cells that were arranged irregularly among follicles in the POI group and get better in the hAEC groups. B. The number of follicles (preantral/antral/atretic follicles) were counted and compared between groups. hAEC treatment groups show more preantral/antra follicles and less atretic follicles than POI group. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001. Scale bar: 100 μm. Magnification ×200. hAEC, human amniotic epithelial cell; H&E, hematoxylin and eosin staining.