Figure 1.

Correlations and relative expressions of HIF-1α and NEAT1 in HCC tissues and their relationships with overall survival of HCC patients. (A and B) HIF-1α (A) and NEAT1 (B) expressions were detected by qRT-PCR and normalized to GAPDH expression in 98 pairs of HCC tissues compared with adjacent nontumourous liver specimens. (C) Spearman’s rank correlation analysis was performed to analyze the correlations of HIF-1α and NEAT1 in HCC tissues. (D and E) Kaplan-Meier survival curve and log-rank test were used to evaluate whether HIF-1α and NEAT1 expression levels were associated with overall survival rate. ***P < 0.001 vs. Adjacent tissue. The data were shown as mean ± standard deviation (S.D.). Abbreviations: HIF-1α, hypoxia-inducible factors-1α; NEAT1, lncRNA nuclear-enriched abundant transcript 1; qRT-PCR, quantitative reverse transcription-polymerase chain reaction; HCC, hepatocellular carcinoma.