Figure 4.

Suppressive effect of MSC-TK on lung metastasis. Schematic illustration of lung metastasis model. MSC-Mock or MSC-TR/TK was intravenously injected into mice, either once or repeatedly over 2 week intervals, starting one week after intravenous injection of LPS246 cells. After engineered MSC treatment, 50 mg/kg of GCV was intraperitoneally injected for 5 consecutive days starting on day 2 (Aa) or on day 16 (Ab). Gross images of tumor burden in the lung of each group after 8 weeks of treatment (n = 2-5 mice/group) (B). Tumor-bearing lung weights (C). **P < 0.01, values are mean ± SD.