Skip to main content
. 2020 Jul 15;12(7):3389–3401.

Figure 5.

Figure 5

Secoemestrin C reduces hepatic Fas and cleaved caspase-3 expression in Con A induced liver injury. Secoemestrin C (SC) was dissolved in DMSO and further diluted with normal saline. Female C57BL/6J mice were intraperitoneally pretreated with SC 10 mg·kg-1 (SC10) or vehicle (normal control, NC) on days-2, -1, and 1 h before i.v. injection with Con A (12 mg·kg-1). (A and B) Liver tissue sections were stained with Fas. Representitive images (A) and bar graph (B) of Fas positive area percentage are shown (magnification: ×200). (C and D) Cleaved caspase-3 was stained and the ratio of apoptotic nuclei to total nuclei (the apoptosis rate) was caculated. Representitive images (C) and bar graph (D) of cleaved caspase 3 positive cells per 103 cells for each group are shown (magnification: ×400). Data are presented with mean ± SEM (three mice per group). **P<0.01 and ***P<0.001 vs. control group; ##P<0.01 and ###P<0.001 vs. Con A group.