Figure 6.

The combination of apatinib and DOX inhibits tumor growth in vivo. The antitumor effect of apatinib, DOX and the combination of both in an MDA-MB-231/ADR human xenograft model. A. Growth curves of xenograft tumors after the subcutaneous injection of MDA-MB-231/ADR cells. The tumor volumes were measured every 2 days after inoculation. B, C. Representative images and weights of tumors excised from mice after inoculation. D. Expression of p50 and p65 extracted from the tumor tissues of drug-administered mice of four groups were detected by western blot analysis. *P<0.05, **P<0.01, vs the control group. ##P<0.01 vs DOX single administration.