Figure 2.

The regulation between TIGIT and immune cells. TIGIT could expressed on both cancer cell and immune cells such as T cell and NK cell. TIGIT inhibitors could suppress the inhibitory function and enhance the T cell and NK cell cytotoxic and anti-tumor function through upregulating the production of IFN-γ and TNF-α. The over expression of TIGIT of T cell could also cause T cell exhaustion, and down regulate the T cell cytotoxic. The NK cell activity could also be upregulation via antibody-dependent cellular cytotoxicity pathway.