Figure 6.

Circ_BICD2 knockdown inhibited the proliferation, migration and metastasis of both OSCC cell by competing binding to miR-107 to decrease HK2 expression. A and B. CCK-8 assay was applied to evaluate the cell proliferation. C and D. Colony formation assay was used to evaluate the colony formation rate. E-H. The migration and invasion capacity of OSCC cells using Transwell assay. I-L. Western blot was performed to measure the protein levels of E-cadherin, N-cadherin and Vimentin. Data are presented as means ± SD of three independent experiments. *P<0.05, **P<0.01, vs the control group; ^#P<0.05, ^##P<0.01, vs the si-HK2 group.