Skip to main content
. 2020 Jul 15;12(7):3557–3576.

Figure 2.

Figure 2

TEM8 promoted proliferation but reduced apoptosis in ovarian cancer cells. A, B. MTT assay showed that TEM8 overexpression increased cell proliferation of ovarian cancer cells, however, these trends were reversed in the TEM8 knockdown groups (n = 9). C-F. Cell cycle assay showed that TEM8 overexpression promoted G0/G1 phase transition of ovarian cancer cells, however, these trends were reversed in the TEM8 knockdown groups (n = 3). G-J. Cell apoptosis assay showed that TEM8 overexpression reduced apoptosis rate of ovarian cancer cells, however, these trends were reversed in the TEM8 knockdown groups (n = 3). K, L. Representative images and quantitation of the western blot showed that the protein expression of Ki-67, cyclin D1, Bcl2, and Bax in the TEM8 overexpression/knockdown groups (n = 3). GAPDH was used as an internal control. Data are presented as mean ± SD. *, P < 0.05; **, P < 0.01; ***, P < 0.001.