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. 2020 Jul 15;12(7):3660–3673.

Figure 6.

Figure 6

miR-424 modulates KGN cell proliferation and apoptosis by suppressing Apelin expression. A. Changes in KGN cell proliferation rate after being treated with multiple combinations of miR-424 inhibitors, LV003-Apelin overexpression construct, and Apelin 13 peptides. Cell proliferation was analyzed by MTS. B, C. Alterations in KGN cell cycle progression after being treated with multiple combinations of miR-424 inhibitors, LV003-Apelin construct, and Apelin 13 peptides. Cell cycle progression was assessed by flow cytometry. D, E. Regulation of KGN cell apoptosis by multiple combinations of miR-424 inhibitors, LV003-Apelin construct, and Apelin 13 peptides. Cell apoptosis was evaluated by flow cytometry. NC: negative control; ns: non-significant difference; * and # indicate P < 0.05.