Figure 3.

Bayesian forecasting based dosing software (blue) initially utilises patient covariates (red), PK properties of the antimicrobial (yellow), and pathogen PD properties (orange) to generate an initial recommended dose that is likely to achieve the PK-PD target associated with maximum efficacy. Resulting plasma exposure concentrations from this dose can then be used to produce a refined PK model that is individualised to a specific patient. A new optimised dose is then produced that is specific to the patient and can be further refined if needed with additional TDM data (green cycle).