Table 2.
Densities (mean ± S.D. fold of control IgG-infused animal level) of 67LR, total kinases, phospho (p)-kinases, and AQP4 in the PC of 67LR IgG-infused animals (*,# p < 0.05 vs. control IgG and vehicle, respectively).
| Inhibitor Proteins |
Vehicle | SB202190 | Wortmannin | 3CAI | U0126 |
|---|---|---|---|---|---|
| 67LR | 1.03 ± 0.03 | 1.04 ± 0.07 | 1.06 ± 0.05 | 1.05 ± 0.06 | 1.05 ± 0.09 |
| P38 MAPK | 1.03 ± 0.09 | 1.05 ± 0.08 | 0.97 ± 0.09 | 1.08 ± 0.07 | 1.06 ± 0.05 |
| p-p38 MAPK | 1.56 ± 0.15 * | 1.16 ± 0.07 *,# | 1.49 ± 0.11 * | 1.48 ± 0.09 * | 1.47 ± 0.13 * |
| PI3K | 0.95 ± 0.08 | 0.94 ± 0.03 | 0.91 ± 0.09 | 0.98 ± 0.07 | 0.92 ± 0.11 |
| p-PI3K | 1.98 ± 0.19 * | 1.20 ± 0.04 # | 1.25 ± 0.10 # | 2.06 ± 0.21 * | 1.52 ± 0.11 *,# |
| AKT | 0.99 ± 0.09 | 0.97 ± 0.08 | 1.00 ± 0.05 | 0.90 ± 0.11 | 0.92 ± 0.08 |
| p-AKT | 1.64 ± 0.10 * | 1.26 ± 0.06 *,# | 1.26 ± 0.15 *,# | 1.23 ± 0.10 *,# | 1.28 ± 0.14 *,# |
| ERK1/2 | 1.02 ± 0.06 | 1.04 ± 0.07 | 1.01 ± 0.04 | 1.10 ± 0.09 | 1.06 ± 0.07 |
| p-ERK1/2 | 1.51 ± 0.08 * | 1.44 ± 0.07 * | 1.26 ± 0.09 *,# | 1.44 ± 0.10 * | 1.11 ± 0.05 *,# |
| AQP4 | 0.57 ± 0.10 * | 0.51 ± 0.11 * | 0.82 ± 0.08 *,# | 0.81 ± 0.08 *,# | 0.79 ± 0.10 *,# |