Table 3.
Densities (mean ± S.D. fold of control animal level) of 67LR, total kinases, phospho (p)-kinases, and AQP4 in the PC of SE-induced animals (*,# p < 0.05 vs. control animal and vehicle, respectively).
| Inhibitor Proteins |
Vehicle | SB202190 | Wortmannin | 3CAI | U0126 |
|---|---|---|---|---|---|
| 67LR | 0.67 ± 0.04 * | 0.65 ± 0.07 * | 0.63 ± 0.05 * | 0.59 ± 0.08 * | 0.61 ± 0.09* |
| P38 MAPK | 1.08 ± 0.09 | 1.07 ± 0.09 | 1.09 ± 0.08 | 1.00 ± 0.07 | 1.01 ± 0.05 |
| p-p38 MAPK | 1.44 ± 0.13 * | 1.16 ± 0.07 *,# | 1.45 ± 0.14 * | 1.43 ± 0.11 * | 1.45 ± 0.15 * |
| PI3K | 0.99 ± 0.04 | 1.01 ± 0.03 | 1.04 ± 0.07 | 0.96 ± 0.07 | 1.01 ± 0.08 |
| p-PI3K | 1.89 ± 0.10 * | 1.38 ± 0.13 *,# | 1.35 ± 0.10 *,# | 1.89 ± 0.12 * | 1.51 ± 0.10 *,# |
| AKT | 1.08 ± 0.09 | 1.01 ± 0.08 | 1.05 ± 0.05 | 0.97 ± 0.11 | 1.05 ± 0.08 |
| p-AKT | 1.73 ± 0.10 * | 1.40 ± 0.11 *,# | 1.32 ± 0.15 *,# | 1.28 ± 0.11 *,# | 1.33 ± 0.16 *,# |
| ERK1/2 | 0.99 ± 0.06 | 1.06 ± 0.07 | 1.05 ± 0.04 | 0.98 ± 0.02 | 0.99 ± 0.03 |
| p-ERK1/2 | 0.59 ± 0.06 * | 0.58 ± 0.08 * | 0.49 ± 0.09 *,# | 0.59 ± 0.09 * | 0.41 ± 0.05 *,# |
| AQP4 | 0.56 ± 0.08 * | 0.56 ± 0.11 * | 0.73 ± 0.07 *,# | 0.71 ± 0.06 *,# | 0.38 ± 0.05 *,# |