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Minimized average structures of AKR1B1 in complexes with different substrates. Panel (A): L-idose; Panel (B): HNE; Panel (C): GSHNE. Substrates are shown in green. The portion of the cofactor adjacent to the ligand binding site is shown in magenta. Relevant protein residues (shown in grey) are indicated. For all components, oxygen atoms are in red, sulfur atoms in yellow, nitrogen atoms in blue, while phosphorous atoms of the cofactor are shown in orange.
