Table 3.
Univariate and multivariate analyses of possible prognostic factors in the patients, according to the Cox proportional-hazards model.
| Variables | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| HR (95% CI) | p-Value | HR (95% CI) | p-Value | |
| Sex (male vs. female) | 0.872 (0.365–2.082) | 0.758 | ||
| Age (years) | 0.980 (0.956–1.006) | 0.127 | ||
| Etiology (HCV vs. HBV) | 0.519 (0.245–1.101) | 0.088 | ||
| Etiology (others vs. HBV) | 0.904 (0.423–1.931) | 0.795 | ||
| Child–Pugh score (6 vs. 5) | 1.630 (0.850–3.154) | 0.141 | ||
| Bone metastasis (yes vs. no) | 1.077 (0.475–2.445) | 0.859 | ||
| Cancer stage (III vs. IV) | 1.009 (0.526–1.935) | 0.979 | ||
| Combination therapy (yes vs. no) | 1.007 (0.508–1.995) | 0.984 | ||
| Therapeutic effect (PD vs. CR/PR/SD) | 3.044 (1.624–5.705) | <0.001 | 3.633 (1.811–7.286) | <0.001 |
| BMI (kg/m2) | 0.954 (0.846–1.075) | 0.440 | ||
| Sarcopenia (yes vs. no) | 1.903 (1.057–3.428) | 0.032 | 1.330 (0.653–2.709) | 0.432 |
| ∆SMIpre (RD vs. non-RD groups) | 0.835 (0.394–1.770) | 0.639 | ||
| ∆SATIpre (RD vs. non-RD groups) | 0.797 (0.390–1.628) | 0.533 | ||
| ∆VATIpre (RD vs. non-RD groups) | 1.001 (0.490–2.046) | 0.998 | ||
| ∆SMIduring (RD vs. non-RD groups) | 3.190 (1.460–6.967) | 0.004 | 1.515 (0.609–3.772) | 0.372 |
| ∆SATIduring (RD vs. non-RD groups) | 3.061 (1.530–6.122) | 0.002 | 3.366 (1.362–8.321) | 0.009 |
| ∆VATIduring (RD vs. non-RD groups) | 2.455 (1.241–4.857) | 0.010 | 1.477 (0.786–2.774) | 0.226 |
| ∆SMIpost (RD vs. non-RD groups) | 2.239 (0.798–6.286) | 0.126 | ||
| ∆SATIpost (RD vs. non-RD groups) | 2.239 (0.798–6.286) | 0.126 | ||
| ∆VATIpost (RD vs. non-RD groups) | 1.280 (0.463–3.535) | 0.634 | ||
HR, hazard ratio; HBV, hepatitis B virus; HCV, hepatitis C virus; CI, confidence interval; PD, progressive disease; CR, complete response; PR, partial response; SD, stable disease; BMI, body mass index; RD, rapid depletion; MD, mild depletion; SMI, skeletal muscle index; SATI, subcutaneous adipose tissue index; VATI, visceral adipose tissue index.