Table 1.

Advantages and disadvantages of each protein nanoparticles.

Material	Advantage	Disadvantage
Silk protein fibroin	High stability Flexibility with high mechanical strength, suitable for various machining conditions Low immunogenicity Biodegradability Biocompatibility	Sericin may cause immunogenic reactions Slow degradation of silk II crystalline antiparallel β-sheet domains
Human serum albumin	High stability High solubility in physiological fluids Biodegradability Non-immunogenicity Non-toxic Availability and readiness	Expensive cost
Gliadin	Biocompatibility Biodegradability Non-immunogenicity Non-toxic High stability	Large particle size Rapid degradation speed
Gelatin	Biocompatibility Biodegradability Ease of bridge Safety	Low mechanical strength Rapid degradation speed
Legumin	Bioadhesive Wide surface area Small particle size Low immunogenicity High stability	Low yield
30Kc19	High stability Increased cell growth and viability Biodegradability Non-immunogenicity Non-toxic Enzyme-stabilizing property Cell-penetrating property	Low nanoparticle size and yield when using only 30Kc19α
Lipoprotein	Non-immunogenicity Biodegradability Biocompatibility Long circulation half-life Naturally targeting property	Difficult to separate native LDL
Ferritin	High stability pH stability Thermal stability Biodegradability	High cost