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Astrocytic expression of adiponectin receptors in 48–52-week-old 5XFAD mice. Double labelling of AdipoR1 (a) with GFAP (b) showed little expression of AdipoR1 in astrocytes (c). Significant colocalisation (f) of AdipoR2 (d) with GFAP (e) demonstrates astrocytic expression of AdipoR2. Images were acquired at 20× magnification. Scale bars for (a–f) are 200 μm. Scale bars for zoomed-in figures are 20 μm.
