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Left panel: A naive situation with one miRNA: miR-A, and one target: transcript-X. Transcript-X harbors miR-A microRNA response elements (MREs) and can be post-transcriptionally regulated by miR-A. Right panel: In the same situation, a new miR-A target is added, transcript-Y. Transcript-Y harbors itself miR-A MREs and can sponge miR-A, thus leading to a reduced post-transcriptional regulation of transcript-X by miR-A through an indirect crosstalk.
