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. 2020 Jul 24;11(7):464–476. doi: 10.5306/wjco.v11.i7.464

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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Adaptive/innate intricate relationship. A demonstration of the interplay between various adaptive (IgG, cytotoxic T-lymphocytes, etc.) and innate (Natural killer cells, macrophages, etc.) factors in the mounting of a full antitumor immune response via cytokines such as interleukin-2 and interferon-gamma. IFNγ: Interferon-gamma: MHC-1: Major histocompatibility complex-1; ADCC: Antibody-dependent cellular cytotoxicity.