Table 3.
Cathepsins in the extracellular space.
| Cathepsin | Substrate | Pathological State | Reference |
|---|---|---|---|
| Cathepsin B, K, and L | proteoglycan | osteoarthritis | [137,165] |
| Cathepsin B, L, G, and S | fibronectin | cancer and adipogenesis | [166,167,168,169] |
| Cathepsin B, L, and S | laminin | cancer neovascularization, intestinal trauma | [166,167,168] |
| Cathepsin K | collagen type I | osteoporosis, rheumatized arthritis, osteoarthritis | [137] |
| Cathepsin B, K, L, and S | collagen type 2 | lung fibrosis, cardiovascular diseases and cancer | [138,139] |
| Cathepsin B | tenascin | cancer | [170] |
| Cathepsin B, K, L, and S | aggrecan | osteoarthritis | [136,171] |
| Cathepsin L, S, and B | plexin | tumorigenesis | [158] |
| Cathepsin S | fractalkine | neuropathic pain | [164] |
| Cathepsin D | fibroblast growth factor | breast cancer | [172] |
| Cathepsin V | elastin | cancer | [173] |
| Cathepsin X | CXCL-12 | - | [174] |
| Cathepsin W | - | cell-mediated cytotoxicity | [175] |
| Cathepsin A, C, E, F, O, and Z * | - | - |
* Role of these extracellular cathepsins in pathologies in not known.