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. 2020 Jun 29;9(7):1578. doi: 10.3390/cells9071578

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Schematic chimeric antigen receptor (CAR) NK cells therapy. (a)NK cells are isolated from patients (autologous), activated, expanded, and then genetically modified to express specific CARs. Therefore, autologous CAR NK cells are administered to the patient. (b) NK cells isolated from healthy donors (allogeneic) are activated and then genetically modified to express specific CARs and consequently expanded. Allogeneic NK cells are then administered to several patients. Allogeneic CAR NK cells can be obtained from different sources, including peripheral blood mononuclear cells (PBMC), NK cell lines, umbilical cord blood (UBC), embryonic cells (ES) or induced pluripotent stem cells (iPSC).