Table 2.
Associations of the clinicopathological characteristics with CHEK1 expression levels in the 126 OSCC patients in this study.
| Patient Characteristics | Number of Patients | No. of Patients (%) | p Value | |
|---|---|---|---|---|
| CHEK1 Low Expression | CHEK1 High Expression | |||
| Sex | ||||
| Male | 114 | 57 (50.0) | 57 (50.0) | 1.000 |
| Female | 12 | 6 (50.0) | 6 (50.0) | |
| Age a (year) | 51.8 ± 11.3 | 52.8 ± 1.2 | 0.336 | |
| Tumor classification | ||||
| T1–T2 | 63 | 33 (52.4) | 30 (47.6) | 0.593 |
| T3–T4 | 63 | 30 (47.6) | 33 (52.4) | |
| Node classification | ||||
| N = 0 | 64 | 38 (59.4) | 26 (40.6) | 0.032 b |
| N > 0 | 62 | 25 (40.3) | 37 (59.7) | |
| Overall TNM stage | ||||
| I–II | 38 | 23 (60.5) | 15 (39.5) | 0.120 |
| III–IV | 88 | 40 (45.5) | 48 (54.5) | |
| Extranodal extension | ||||
| No | 94 | 49 (52.1) | 45 (47.9) | 0.413 |
| Yes | 32 | 14 (43.8) | 18 (56.2) | |
| Perineural invasion | ||||
| No | 68 | 36 (52.9) | 32 (47.1) | 0.475 |
| Yes | 58 | 27 (46.6) | 31 (53.4) | |
| Differentiation c | ||||
| Well + Mod | 110 | 57 (51.8) | 53 (48.2) | 0.285 |
| Poor | 16 | 6 (37.5) | 10 (62.5) | |
| Tumor depth | ||||
| mm | 14.3 ± 9.5 | 13.5 ± 10.3 | 0.475 | |
a Mean ± SD. b Statistically significant. c Well: well-differentiated squamous cell carcinoma; Mod: moderately differentiated squamous cell carcinoma; Poor: poorly differentiated squamous cell carcinoma.