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. 2020 Jul 7;12(7):641. doi: 10.3390/pharmaceutics12070641

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Characterization of N-AI-loaded liposomes. (a) Representative cryo-TEM image of N-AI-loaded liposomes. (b) Determination of the average liposome diameter from cryo-TEM image analysis. (c) Size-exclusion chromatograph of the PAI-2 liposome fractions after conjugation, including PAI-2 liposomes (peak 1) and unbound PAI-2 (peak 2). (d) Western blot detection of PAI-2 in size-exclusion fractions (1, 2), un-purified liposomes (3), and purified PAI-2 (50, 25 and 12.5 ng). OD = optical density, M = marker, PEG = polyethylene glycol. (e) Kinetic inhibition curves for unconjugated PAI-2 versus PAI-2 conjugated to empty liposomes (EMP PAI-2), against uPA in solution. Empty liposomes were included as a fluorescence control. Values are means ± s.d. (n = 3).